Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.

Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the differences between sCT and hCT on the human calcitonin receptor (CT(a)R) with respect to activation of cAMP signaling, β-arrestin recruitment, l...

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Bibliographic Details
Main Authors: Kim Vietz Andreassen, Sara Toftegaard Hjuler, Sebastian G Furness, Patrick M Sexton, Arthur Christopoulos, Olivier Nosjean, Morten Asser Karsdal, Kim Henriksen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3958426?pdf=render

Internet

http://europepmc.org/articles/PMC3958426?pdf=render

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