Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells

Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells

A hallmark of pulmonary tuberculosis is the formation of macrophage-rich granulomas. These may restrict Mycobacterium tuberculosis (Mtb) growth, or progress to central necrosis and cavitation, facilitating pathogen growth. To determine factors leading to Mtb proliferation and host cell death, we use...

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Bibliographic Details
Main Authors: Deeqa Mahamed, Mikael Boulle, Yashica Ganga, Chanelle Mc Arthur, Steven Skroch, Lance Oom, Oana Catinas, Kelly Pillay, Myshnee Naicker, Sanisha Rampersad, Colisile Mathonsi, Jessica Hunter, Emily B Wong, Moosa Suleman, Gopalkrishna Sreejit, Alexander S Pym, Gila Lustig, Alex Sigal
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
Mycobacterium tuberculosis
human macrophages
live cell imaging
infection dynamics
necrosis
Online Access:https://elifesciences.org/articles/22028

Internet

https://elifesciences.org/articles/22028

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