AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a novel Müller cell-specific Crb1KOCrb2LowMGC retinitis pigmentosa mouse model (complete loss of CRB1 and reduced levels...

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Bibliographic Details
Main Authors: Thilo M. Buck, Rogier M. Vos, C. Henrique Alves, Jan Wijnholds
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
retinitis pigmentosa
CRB1
CRB2
Müller glial cell
adeno-associated viral vector
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302606

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http://www.sciencedirect.com/science/article/pii/S2329050120302606

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