Three repeat isoforms of tau inhibit assembly of four repeat tau filaments.

Three repeat isoforms of tau inhibit assembly of four repeat tau filaments.

Tauopathies are defined by assembly of the microtubule associated protein tau into filamentous tangles and classified by the predominant tau isoform within these aggregates. The major isoforms are determined by alternative mRNA splicing of exon 10 generating tau with three (3R) or four (4R) approxim...

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Bibliographic Details
Main Authors: Stephanie J Adams, Michael A DeTure, Melinda McBride, Dennis W Dickson, Leonard Petrucelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2876030?pdf=render

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http://europepmc.org/articles/PMC2876030?pdf=render

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