PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

Tissue integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. In the skin, hair follicle stem cells (HFSCs) that reside within the bulge maintain tissue homeostasis in response to activating cues that occur with each new hair cycle or upon injury. We found...

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Bibliographic Details
Main Authors: Chiara Zagni, Luciana O. Almeida, Tarek Balan, Marco T. Martins, Luciana K. Rosselli-Murai, Petros Papagerakis, Rogerio M. Castilho, Cristiane H. Squarize
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
stem cell
niche
senescence
skin
epidermal homeostasis
PTEN
clock genes
circadian rhythm
Bmal1
AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302138

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http://www.sciencedirect.com/science/article/pii/S2213671117302138

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