Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.

Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.

Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV(1)) before and after the administration of a short-acting β(2)-agonist, the most common rescue medications used for the treatment of asthma. BDR also...

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Bibliographic Details
Main Authors: Blanca E Himes, Xiaofeng Jiang, Ruoxi Hu, Ann C Wu, Jessica A Lasky-Su, Barbara J Klanderman, John Ziniti, Jody Senter-Sylvia, John J Lima, Charles G Irvin, Stephen P Peters, Deborah A Meyers, Eugene R Bleecker, Michiaki Kubo, Mayumi Tamari, Yusuke Nakamura, Stanley J Szefler, Robert F Lemanske, Robert S Zeiger, Robert C Strunk, Fernando D Martinez, John P Hanrahan, Gerard H Koppelman, Dirkje S Postma, Maartje A E Nieuwenhuis, Judith M Vonk, Reynold A Panettieri, Amy Markezich, Elliot Israel, Vincent J Carey, Kelan G Tantisira, Augusto A Litonjua, Quan Lu, Scott T Weiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3390407?pdf=render

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http://europepmc.org/articles/PMC3390407?pdf=render

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