The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates in the aging brain and is a feature of HD. We soug...

Full description

Bibliographic Details
Main Authors: Emily Machiela, Ritika Jeloka, Nicholas S. Caron, Shagun Mehta, Mandi E. Schmidt, Helen J. E. Baddeley, Colton M. Tom, Nalini Polturi, Yuanyun Xie, Virginia B. Mattis, Michael R. Hayden, Amber L. Southwell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Huntington (disease)
iPSC (induced pluripotent stem cell)
primary neuron culture
mouse models of disease
neurodegenaration
DNA damage
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.524369/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.524369/full

Similar Items