Batch effects account for the main findings of an in utero human intestinal bacterial colonization study

Abstract A recent study by Rackaityte et al. reported evidence for a low level of bacterial colonization, specifically of Micrococcus luteus, in the intestine of second trimester human fetuses. We have re-analyzed their sequence data and identified a batch effect which violates the underlying assump...

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Bibliographic Details
Main Authors: Marcus C. de Goffau, D. Stephen Charnock-Jones, Gordon C. S. Smith, Julian Parkhill
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Microbiome
Subjects:
Online Access:https://doi.org/10.1186/s40168-020-00949-z