Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been suggested that modulation of neuronal activity may alter Aβ production in the brain. We postulate that these changes in Aβ production are due to change...

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Bibliographic Details
Main Authors: Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M. Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T. Hyman, Oksana Berezovska
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Presenilin 1
Amyloid β precursor protein
FLIM (fluorescence lifetime imaging microscopy)
Neuronal activity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003300

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http://www.sciencedirect.com/science/article/pii/S0969996112003300

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