Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma.

Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma.

To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell-carcinoma (MRCC) and to evaluate in vitro their mechanism of action in sunitinib resistance.We screened 673 microRNAs using TaqMan Low-density-Arrays (TLDAs) in tumors from MRCC patients with extreme...

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Main Authors: Celia Prior, Jose Luis Perez-Gracia, Jesus Garcia-Donas, Cristina Rodriguez-Antona, Elizabeth Guruceaga, Emilio Esteban, Cristina Suarez, Daniel Castellano, Aránzazu González del Alba, Maria Dolores Lozano, Joan Carles, Miguel Angel Climent, Jose Angel Arranz, Enrique Gallardo, Javier Puente, Joaquim Bellmunt, Alfonso Gurpide, Jose Maria Lopez-Picazo, Alvaro Gonzalez Hernandez, Begoña Mellado, Esther Martínez, Fernando Moreno, Albert Font, Alfonso Calvo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3901669?pdf=render

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http://europepmc.org/articles/PMC3901669?pdf=render

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