Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin

Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin

The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and the mechanism involved. The study was performed in C57B/6J mice fed a MCD diet for 6 weeks to induce NASH with or without the treatment of ma...

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Bibliographic Details
Main Authors: Ali Mahzari, Songpei Li, Xiu Zhou, Dongli Li, Sherouk Fouda, Majid Alhomrani, Wala Alzahrani, Stephen R. Robinson, Ji-Ming Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
matrine
NASH
inflammation
fibrosis
HSP72
mTOR
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00405/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00405/full

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