Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective

Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective

Type 2 diabetes (T2D) is a well-known risk factor for tuberculosis (TB), but little is known about pre-diabetes and the relative contribution of impaired glucose tolerance vs. obesity towards susceptibility to TB. Here, we developed a preclinical model of pre-diabetes and TB. Mice fed a high fat die...

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Bibliographic Details
Main Authors: Roma Sinha, Minh Dao Ngo, Stacey Bartlett, Helle Bielefeldt-Ohmann, Sahar Keshvari, Sumaira Z. Hasnain, Meg L. Donovan, Jessica C. Kling, Antje Blumenthal, Chen Chen, Kirsty R. Short, Katharina Ronacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
impaired glucose tolerance
high fat diet
disease severity
pre-diabetes
diabetes
Mycobacterium tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.691823/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.691823/full

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