Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

<p>Abstract</p> <p>Background</p> <p>The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD), and that its genetic absence results in a r...

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Bibliographic Details
Main Authors: Chu Jin, Giannopoulos Phillip F, Ceballos-Diaz Carolina, Golde Todd E, Pratico Domenico
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer's disease
animal model
amyloid beta
5-Lipoxygenase
Online Access:http://www.molecularneurodegeneration.com/content/7/1/1

Internet

http://www.molecularneurodegeneration.com/content/7/1/1

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