Mendelian randomization for studying the effects of perturbing drug targets [version 2; peer review: 2 approved, 1 approved with reservations]

Mendelian randomization for studying the effects of perturbing drug targets [version 2; peer review: 2 approved, 1 approved with reservations]

Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be used in Mendelian randomization analyses to offer i...

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Bibliographic Details
Main Authors: Dipender Gill, Marios K. Georgakis, Venexia M. Walker, A. Floriaan Schmidt, Apostolos Gkatzionis, Daniel F. Freitag, Chris Finan, Aroon D. Hingorani, Joanna M.M. Howson, Stephen Burgess, Daniel I. Swerdlow, George Davey Smith, Michael V. Holmes, Martin Dichgans, Robert A Scott, Jie Zheng, Bruce M. Psaty, Neil M. Davies
Format: Article
Language:English
Published: Wellcome 2021-02-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/6-16/v2

Internet

https://wellcomeopenresearch.org/articles/6-16/v2

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