Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication

Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication

Abstract Treatment options for COVID-19 remain limited, especially during the early or asymptomatic phase. Here, we report a novel SARS-CoV-2 viral replication mechanism mediated by interactions between ACE2 and the epigenetic eraser enzyme LSD1, and its interplay with the nuclear shuttling importin...

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Bibliographic Details
Main Authors: Wen Juan Tu, Robert D. McCuaig, Michelle Melino, Daniel J. Rawle, Thuy T. Le, Kexin Yan, Andreas Suhrbier, Rebecca L. Johnston, Lambros T. Koufariotis, Nicola Waddell, Emily M. Cross, Sofiya Tsimbalyuk, Amanda Bain, Elizabeth Ahern, Natasha Collinson, Simon Phipps, Jade K. Forwood, Nabila Seddiki, Sudha Rao
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00279-w

Internet

https://doi.org/10.1038/s41421-021-00279-w

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