P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b

Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca<sup>2+</sup> pump isoform 4b (PMCA4b or <i>ATP2B4</i>) as a putative metastasis suppressor in BRAF mutant melanoma cells. Metastasis suppressors are often downregu...

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Bibliographic Details
Main Authors: Randa Naffa, Lisa Vogel, Luca Hegedűs, Katalin Pászty, Sarolta Tóth, Kornélia Kelemen, Neha Singh, Attila Reményi, Enikő Kállay, Mihály Cserepes, József Tóvári, Michael Grusch, Ágnes Enyedi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
plasma membrane Ca<sup>2+</sup>ATPase isoform 4b
p38 mitogen-activated protein kinase (MAPK)
endocytosis
calcium signaling
BRAF mutant melanoma
metastasis
Online Access:https://www.mdpi.com/2073-4409/9/5/1209

Internet

https://www.mdpi.com/2073-4409/9/5/1209

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