The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma

The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma

The receptor tyrosine kinase (RTK) RON is linked to an aggressive metastatic phenotype of carcinomas. While gaining interest as a therapeutic target, RON remains unstudied in sarcomas. In Ewing sarcoma, we identified RON among RTKs conferring resistance to insulin-like growth factor-1 receptor (IGF1...

Full description

Bibliographic Details
Main Authors: Philipp Berning, Carolin Hennemann, Claudia Tulotta, Christiane Schaefer, Birgit Lechtape, Marc Hotfilder, Yassmine El Gourari, Heribert Jürgens, Ewa Snaar-Jagalska, Georg Hempel, Uta Dirksen, Jenny Potratz
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
RON
MST1R
isoforms
IMC-RON8
narnatumab
IMC-A12
Online Access:https://www.mdpi.com/2072-6694/12/4/904

Internet

https://www.mdpi.com/2072-6694/12/4/904

Similar Items