Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer

Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer

Abstract GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly expressed on regulatory T lymphocytes and platelets. GARP regulates the availability of membrane-bound latent TGF-β and mo...

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Bibliographic Details
Main Authors: Alessandra Metelli, Mohammad Salem, Caroline H. Wallace, Bill X. Wu, Anqi Li, Xue Li, Zihai Li
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Hematology & Oncology
Subjects:
TGF-β
GARP
Treg
Immune tolerance
Cancer
Platelets
Online Access:http://link.springer.com/article/10.1186/s13045-018-0570-z

Internet

http://link.springer.com/article/10.1186/s13045-018-0570-z

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