Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.

Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.

Structural restrictions are present even in the most sequence diverse portions of antibodies, the complementary determining region (CDR) loops. Previous studies identified robust rules that define canonical structures for five of the six CDR loops, however the heavy chain CDR 3 (HCDR3) defies standa...

Full description

Bibliographic Details
Main Authors: Jessica A Finn, Julia Koehler Leman, Jordan R Willis, Alberto Cisneros, James E Crowe, Jens Meiler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4868311?pdf=render

Internet

http://europepmc.org/articles/PMC4868311?pdf=render

Similar Items