An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.
Atypical protein kinase C (aPKC) isoforms have been implicated in cell polarisation and migration through association with Cdc42 and Par6. In distinct migratory models, the Exocyst complex has been shown to be involved in secretory events and migration. By RNA interference (RNAi) we show that the po...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-11-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2762617?pdf=render |