EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

Replication fork stalling and collapse is a major source of genome instability leading to neoplastic transformation or cell death. Such stressed replication forks can be conservatively repaired and restarted using homologous recombination (HR) or non-conservatively repaired using micro-homology medi...

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Bibliographic Details
Main Authors: Yuehan Wu, Suk-Hee Lee, Elizabeth A Williamson, Brian L Reinert, Ju Hwan Cho, Fen Xia, Aruna Shanker Jaiswal, Gayathri Srinivasan, Bhavita Patel, Alexis Brantley, Daohong Zhou, Lijian Shao, Rupak Pathak, Martin Hauer-Jensen, Sudha Singh, Kimi Kong, Xaiohua Wu, Hyun-Suk Kim, Timothy Beissbarth, Jochen Gaedcke, Sandeep Burma, Jac A Nickoloff, Robert A Hromas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4684289?pdf=render

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http://europepmc.org/articles/PMC4684289?pdf=render

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