Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

Abstract Background SAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells by its dNTP triphosphorylase activity that depletes cellular dNTPs. However, HIV-2 and some SIV strains rapidl...

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Bibliographic Details
Main Authors: Bijan Mahboubi, Christina Gavegnano, Dong-Hyun Kim, Raymond F. Schinazi, Baek Kim
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Retrovirology
Subjects:
HIV-1
HIV-2
Reverse transcription
Endogenous reverse transcription
SAMHD1
Vpx
Online Access:http://link.springer.com/article/10.1186/s12977-018-0452-z

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http://link.springer.com/article/10.1186/s12977-018-0452-z

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