Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

Abstract Background Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic opportunities. Recently, splicing factors have gained attention as potential targets for cancer treatment. Here we systematically evaluated the role of RNA splicing factors in...

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Bibliographic Details
Main Authors: Esmee Koedoot, Eline van Steijn, Marjolein Vermeer, Román González-Prieto, Alfred C. O. Vertegaal, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Triple-negative breast cancer
Mitosis
Sister chromatid cohesion
RNA splicing
Splicing factors
Proliferation
Online Access:https://doi.org/10.1186/s13046-021-01863-4

Internet

https://doi.org/10.1186/s13046-021-01863-4

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