Premature Senescence and Increased Oxidative Stress in the Thymus of Down Syndrome Patients

Premature Senescence and Increased Oxidative Stress in the Thymus of Down Syndrome Patients

Down syndrome (DS) patients prematurely show clinical manifestations usually associated with aging. Their immune system declines earlier than healthy individuals, leading to increased susceptibility to infections and higher incidence of autoimmune phenomena. Clinical features of accelerated aging in...

Full description

Bibliographic Details
Main Authors: Genni Enza Marcovecchio, Francesca Ferrua, Elena Fontana, Stefano Beretta, Marco Genua, Ileana Bortolomai, Anastasia Conti, Davide Montin, Maria Teresa Cascarano, Sonia Bergante, Veronica D’Oria, Alessandro Giamberti, Donato Amodio, Caterina Cancrini, Adriano Carotti, Raffaella Di Micco, Ivan Merelli, Marita Bosticardo, Anna Villa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
Down syndrome
thymus
thymic epithelial cells
senescence
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.669893/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.669893/full

Similar Items