Protocol for a mouse CNS demyelination model induced by a combination of HSV-1 and IL-2

Summary: Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. Although viruses have been suggested to be a contributing environmental factor, conventional experimental MS mouse models do not account for this aspect. Here, we describe a mouse model to induce a...

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Bibliographic Details
Main Authors: Satoshi Hirose, Kati Tormanen, Mihoko Kato, Jack Yu, Homayon Ghiasi
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166720302744