Microglia-specific targeting by novel capsid-modified AAV6 vectors

Microglia-specific targeting by novel capsid-modified AAV6 vectors

Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, are refractile to rAAV. To identify AAV capsids wit...

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Bibliographic Details
Main Authors: Awilda M Rosario, Pedro E Cruz, Carolina Ceballos-Diaz, Michael R Strickland, Zoe Siemienski, Meghan Pardo, Keri-Lyn Schob, Andrew Li, George V Aslanidi, Arun Srivastava, Todd E Golde, Paramita Chakrabarty
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301681

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http://www.sciencedirect.com/science/article/pii/S2329050116301681

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