Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice

Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice

Loss-of-function mutations in progranulin (GRN), most of which cause progranulin haploinsufficiency, are a major autosomal dominant cause of frontotemporal dementia (FTD). Individuals with loss-of-function mutations on both GRN alleles develop neuronal ceroid lipofuscinosis (NCL), a lysosomal storag...

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Bibliographic Details
Main Authors: Andrew E. Arrant, Anthony J. Filiano, Aashka R. Patel, Madelyn Q. Hoffmann, Nicholas R. Boyle, Shreya N. Kashyap, Vincent C. Onyilo, Allen H. Young, Erik D. Roberson
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Neuron
Microglia
Progranulin
Frontotemporal dementia
Neuronal ceroid lipofuscinosis
Pathology
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611830696X

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http://www.sciencedirect.com/science/article/pii/S096999611830696X

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