Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling

Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling

Previous work in yeast has suggested that modification of tRNAs, in particular uridine bases in the anticodon wobble position (U34), is linked to TOR (target of rapamycin) signaling. Hence, U34 modification mutants were found to be hypersensitive to TOR inhibition by rapamycin. To study whether this...

Full description

Bibliographic Details
Main Authors: Viktor Scheidt, André Jüdes, Christian Bär, Roland Klassen, Raffael Schaffrath
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-11-01
Series:Microbial Cell
Subjects:
Saccharomyces cerevisiae
TOR signaling
rapamycin
Gln3
NCR
Sit4
Elongator complex
tRNA anticodon modification
tRNase zymocin
Online Access:http://microbialcell.com/researcharticles/loss-of-wobble-uridine-modification-in-trna-anticodons-interferes-with-tor-pathway-signaling/

Internet

http://microbialcell.com/researcharticles/loss-of-wobble-uridine-modification-in-trna-anticodons-interferes-with-tor-pathway-signaling/

Similar Items