PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

Pregnane X receptor (PXR) is a liver-enriched xenobiotic-responsive transcription factor. Although recent studies suggest that PXR shows anti-inflammatory effects by suppressing nuclear factor kappa B (NF-κB), the detailed mechanism remains unclear. In this study, we aimed to elucidate this mechanis...

Full description

Bibliographic Details
Main Authors: Maya Okamura, Ryota Shizu, Taiki Abe, Susumu Kodama, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
PXR
NF-κB
AP-1
chemokine
CXCL2
nuclear receptor
Online Access:https://www.mdpi.com/2073-4409/9/10/2296

Internet

https://www.mdpi.com/2073-4409/9/10/2296

Similar Items