Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.

Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.

Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. However, the molecular alterations identified th...

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Bibliographic Details
Main Authors: Kelsie L Thu, Emily A Vucic, Raj Chari, Wei Zhang, William W Lockwood, John C English, Rong Fu, Pei Wang, Ziding Feng, Calum E MacAulay, Adi F Gazdar, Stephen Lam, Wan L Lam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3296775?pdf=render

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http://europepmc.org/articles/PMC3296775?pdf=render

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