Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model.

Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model.

Direct conversion from fibroblasts to generate hepatocyte like-cells (iHeps) bypassing the pluripotent state has been described in previous reports as an attractive method acquiring hepatocytes for cell-based therapy. The limited proliferation of iHeps, however, has hampered it uses in cell-based th...

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Main Authors: Myung Rae Park, Man Sze Wong, Marcos J Araúzo-Bravo, Hyunah Lee, Donggyu Nam, Soo Yong Park, Hong Dae Seo, Sang Min Lee, Hans Florian Zeilhofer, Holm Zaehres, Hans R Schöler, Jeong Beom Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221085

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https://doi.org/10.1371/journal.pone.0221085

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