A metastable subproteome underlies inclusion formation in muscle proteinopathies

A metastable subproteome underlies inclusion formation in muscle proteinopathies

Abstract Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and form a metastable subproteome. It is not yet clear, however, w...

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Bibliographic Details
Main Authors: Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo, Conrad C. Weihl
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-019-0853-9

Internet

https://doi.org/10.1186/s40478-019-0853-9

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