Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

<h4>Background</h4>A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ul...

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Main Authors: Adam Penn-Nicholson, Thomas Hraha, Ethan G Thompson, David Sterling, Stanley Kimbung Mbandi, Kirsten M Wall, Michelle Fisher, Sara Suliman, Smitha Shankar, Willem A Hanekom, Nebojsa Janjic, Mark Hatherill, Stefan H E Kaufmann, Jayne Sutherland, Gerhard Walzl, Mary Ann De Groote, Urs Ochsner, Daniel E Zak, Thomas J Scriba, ACS and GC6–74 cohort study groups
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1002781

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https://doi.org/10.1371/journal.pmed.1002781

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