Multinomial modelling of TB/HIV co-infection yields a robust predictive signature and generates hypotheses about the HIV+TB+ disease state.

by Fergal J Duffy, Ethan G Thompson, Thomas J Scriba, Daniel E Zak
Published 2019-01-01

Correction: Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics.

by Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich
Published 2008-03-01

Correction: Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics.

by Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich
Published 2008-04-01

Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.

by Stephen A Ramsey, Sandy L Klemm, Daniel E Zak, Kathleen A Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S Gold, Carrie D Johnson, Vladimir Litvak, Garnet Navarro, Jared C Roach, Carrie M Rosenberger, Alistair G Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich
Published 2008-03-01

The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection

by Ying Du, Ethan G. Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A. van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff, Jenny Hendriks, Malcolm J. Gardner, W. Ripley Ballou, Jason A. Regules, Robbert van der Most, Alan Aderem, Christian F. Ockenhouse, Adrian V. Hill, Ulrike Wille-Reece, Daniel E. Zak
Published 2020-04-01

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

by Adam Penn-Nicholson, Thomas Hraha, Ethan G Thompson, David Sterling, Stanley Kimbung Mbandi, Kirsten M Wall, Michelle Fisher, Sara Suliman, Smitha Shankar, Willem A Hanekom, Nebojsa Janjic, Mark Hatherill, Stefan H E Kaufmann, Jayne Sutherland, Gerhard Walzl, Mary Ann De Groote, Urs Ochsner, Daniel E Zak, Thomas J Scriba, ACS and GC6–74 cohort study groups
Published 2019-04-01

Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

by Adam Penn-Nicholson, Thomas Hraha, Ethan G Thompson, David Sterling, Stanley Kimbung Mbandi, Kirsten M Wall, Michelle Fisher, Sara Suliman, Smitha Shankar, Willem A Hanekom, Nebojsa Janjic, Mark Hatherill, Stefan H E Kaufmann, Jayne Sutherland, Gerhard Walzl, Mary Ann De Groote, Urs Ochsner, Daniel E Zak, Thomas J Scriba, ACS and GC6–74 cohort study groups
Published 2019-07-01

Metabolite changes in blood predict the onset of tuberculosis

by January Weiner, Jeroen Maertzdorf, Jayne S. Sutherland, Fergal J. Duffy, Ethan Thompson, Sara Suliman, Gayle McEwen, Bonnie Thiel, Shreemanta K. Parida, Joanna Zyla, Willem A. Hanekom, Robert P. Mohney, W. Henry Boom, Harriet Mayanja-Kizza, Rawleigh Howe, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, Stefan H. E. Kaufmann, The GC6-74 consortium
Published 2018-12-01

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.

by Thomas J Scriba, Adam Penn-Nicholson, Smitha Shankar, Tom Hraha, Ethan G Thompson, David Sterling, Elisa Nemes, Fatoumatta Darboe, Sara Suliman, Lynn M Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, John L Johnson, W Henry Boom, Mark Hatherill, Joe Valvo, Mary Ann De Groote, Urs A Ochsner, Alan Aderem, Willem A Hanekom, Daniel E Zak, other members of the ACS cohort study team
Published 2017-11-01

Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial

by Daniel F. Hoft, Azra Blazevic, Asmir Selimovic, Aldin Turan, Jan Tennant, Getahun Abate, John Fulkerson, Daniel E. Zak, Robert Walker, Bruce McClain, Jerry Sadoff, Judy Scott, Barbara Shepherd, Jasur Ishmukhamedov, David A. Hokey, Veerabadran Dheenadhayalan, Smitha Shankar, Lynn Amon, Garnet Navarro, Rebecca Podyminogin, Alan Aderem, Lew Barker, Michael Brennan, Robert S. Wallis, Anne A. Gershon, Michael D. Gershon, Sharon Steinberg
Published 2016-05-01

Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral Therapy

by Fatoumatta Darboe, Stanley Kimbung Mbandi, Kogieleum Naidoo, Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Nonhlanhla Yende-Zuma, Lara Lewis, Ethan G. Thompson, Fergal J. Duffy, Michelle Fisher, Elizabeth Filander, Michele van Rooyen, Nicole Bilek, Simbarashe Mabwe, Lyle R. McKinnon, Lyle R. McKinnon, Novel Chegou, Andre Loxton, Gerhard Walzl, Gerard Tromp, Gerard Tromp, Nesri Padayatchi, Nesri Padayatchi, Dhineshree Govender, Mark Hatherill, Salim Abdool Karim, Salim Abdool Karim, Salim Abdool Karim, Daniel E. Zak, Adam Penn-Nicholson, Thomas J. Scriba, The SATVI Clinical Immunology Team
Published 2019-06-01

The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment

by Trust Odia, Trust Odia, Trust Odia, Trust Odia, Trust Odia, Stephanus T. Malherbe, Stephanus T. Malherbe, Stephanus T. Malherbe, Stuart Meier, Stuart Meier, Stuart Meier, Stuart Meier, Stuart Meier, Elizna Maasdorp, Elizna Maasdorp, Elizna Maasdorp, Elizna Maasdorp, Elizna Maasdorp, Léanie Kleynhans, Léanie Kleynhans, Léanie Kleynhans, Nelita du Plessis, Nelita du Plessis, Nelita du Plessis, Andre G. Loxton, Andre G. Loxton, Andre G. Loxton, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Fergal J. Duffy, Helena Kuivaniemi, Helena Kuivaniemi, Helena Kuivaniemi, Katharina Ronacher, Katharina Ronacher, Katharina Ronacher, Katharina Ronacher, Jill Winter, Gerhard Walzl, Gerhard Walzl, Gerhard Walzl, Gerhard Walzl, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, the Catalysis TB-Biomarker Consortium, André G. Loxton, Annare Ellman, Bronwyn Smith, Caroline G. G. Beltran, Clifton E. Barry, David Alland, Friedrich Thienemann, Gerard Tromp, Gerhard Walzl, James M. Warwick, Jill Winter, Katharina Ronacher, Kim Stanley, Ilse Kant, Lani Thiart, Lance A. Lucas, Laura E. Via, Lori E. Dodd, Magdalena Kriel, Nelita Plessis Du, Patrick Dupont, Ray Y. Chen, Robert J. Wilkinson, Shubhada Shenai, Stephanie Griffith-Richards, Stephanus T. Malherbe
Published 2021-02-01

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts

by Fergal J. Duffy, Ethan Thompson, Katrina Downing, Sara Suliman, Harriet Mayanja-Kizza, Harriet Mayanja-Kizza, W. Henry Boom, Bonnie Thiel, January Weiner III, Stefan H. E. Kaufmann, Drew Dover, David L. Tabb, Hazel M. Dockrell, Tom H. M. Ottenhoff, Gerard Tromp, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, the GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. Loxton, N. N. Chegou, S. Suliman, T. Scriba, H. Mahomed, M. Erasmus, O. Xasa, A. Veldsman, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong C, W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Published 2018-04-01

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

by Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Published 2019-03-01