Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

Objective: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or n...

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Bibliographic Details
Main Authors: Bhagirath Chaurasia, Li Ying, Chad Lamar Talbot, John Alan Maschek, James Cox, Edward H. Schuchman, Yoshio Hirabayashi, William L. Holland, Scott A. Summers
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Metabolism
Subjects:
Ceramides
Sphingolipids
brown adipose tissue
Obesity
Insulin resistance
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820302192

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http://www.sciencedirect.com/science/article/pii/S2212877820302192

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