Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling

Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling

IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t...

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Bibliographic Details
Main Authors: Suzanne Cole, Janine Murray, Catherine Simpson, Remi Okoye, Kerry Tyson, Meryn Griffiths, Dominique Baeten, Stevan Shaw, Asher Maroof
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
IL-17A
IL-17F
Th17
IL-23
mucosal associated invariant T cell
innate lymphoid cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.585134/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.585134/full

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