Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients

Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients

Purpose: Anti-PD-1 therapy has revolutionized the treatment and improved the survival of stage IV melanoma patients. However, almost half of the patients fail to respond due to immune evasive mechanism. A known mechanism is the downregulation of major histocompatibility complex (MHC) class I express...

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Bibliographic Details
Main Authors: Hansol Lee, Camelia Quek, Ines Silva, Annie Tasker, Marcel Batten, Helen Rizos, Su Yin Lim, Tuba Nur Gide, Ping Shang, Grace H. Attrill, Jason Madore, Jarem Edwards, Matteo S. Carlino, Alexander Guminski, Robyn P.M. Saw, John F. Thompson, Peter M. Ferguson, Umaimainthan Palendira, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, James S. Wilmott
Format: Article
Language:English
Published: Taylor & Francis Group 2019-02-01
Series:OncoImmunology
Subjects:
melanoma
nk cells
mhc class i
anti-pd-1 therapy
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1537581

Internet

http://dx.doi.org/10.1080/2162402X.2018.1537581

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