Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control

Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control

RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific RORα ‘gain of function’ mouse model under the control of the fatty acid bi...

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Bibliographic Details
Main Authors: Zewen Kelvin Tuong, Rebecca Fitzsimmons, Shu-Ching Mary Wang, Tae Gyu Oh, Patrick Lau, Frederik Steyn, Gethin Thomas, George E.O. Muscat
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:EBioMedicine
Subjects:
RORα
Subcutaneous adipose
Obesity
Hepatomegaly
Fibrosis
Collagen
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303760

Internet

http://www.sciencedirect.com/science/article/pii/S2352396416303760

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