Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs

Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs

The pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has stimulated the search for antivirals to tackle COVID-19 infection. Molecules with known pharmacokinetics and already approved for human use have been demonstrated or predicted to be suitable to be used either dire...

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Bibliographic Details
Main Authors: Bruno Rizzuti, Fedora Grande, Filomena Conforti, Ana Jimenez-Alesanco, Laura Ceballos-Laita, David Ortega-Alarcon, Sonia Vega, Hugh T. Reyburn, Olga Abian, Adrian Velazquez-Campoy
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomedicines
Subjects:
rutin
quercetin
SARS-CoV-2
drug selection
enzyme inhibitors
antivirals
Online Access:https://www.mdpi.com/2227-9059/9/4/375

Internet

https://www.mdpi.com/2227-9059/9/4/375

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