A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

Abstract Background Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown. Methods We performed a large transcriptome-wide association study (TWAS) leveragin...

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Bibliographic Details
Main Authors: Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy J. Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Medicine
Subjects:
Alzheimer’s disease
Transcriptome-wide association study
Susceptibility genes
Etiology
Online Access:https://doi.org/10.1186/s13073-021-00959-y

Internet

https://doi.org/10.1186/s13073-021-00959-y

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