Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.

While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a "fetal re-expression" pattern, the functional role of Myc in mechanisms of cardiomyopathy remains unclear. To address this, we developed a bitransgenic mouse that...

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Bibliographic Details
Main Authors: Hyoung-gon Lee, Qun Chen, Julie A Wolfram, Sandy L Richardson, Anna Liner, Sandra L Siedlak, Xiongwei Zhu, Nicholas P Ziats, Hisashi Fujioka, Dean W Felsher, Rudy J Castellani, Maria L Valencik, John A McDonald, Brian D Hoit, Edward J Lesnefsky, Mark A Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2747003?pdf=render

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http://europepmc.org/articles/PMC2747003?pdf=render

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