Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

Abstract Background Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It is increasingly recognized that innate immune responses by brain myeloi...

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Bibliographic Details
Main Authors: Hongtian Yang, Leah C. Graham, Alaina M. Reagan, Weronika A. Grabowska, William H. Schott, Gareth R. Howell
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Neuroinflammation
Subjects:
Obesity
Western diet
Myeloid cells
Microglia
Monocytes
Neutrophils
Online Access:http://link.springer.com/article/10.1186/s12974-019-1527-z

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http://link.springer.com/article/10.1186/s12974-019-1527-z

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