Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice

by Kate E. Foley, Hongtian Stanley Yang, Leah C. Graham, Gareth R. Howell
Published 2019-11-01

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

by Ravi S. Pandey, Leah Graham, Asli Uyar, Christoph Preuss, Gareth R. Howell, Gregory W. Carter
Published 2019-12-01

Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.

by Ryan H Berry, Juan Qu, Simon W M John, Gareth R Howell, Tatjana C Jakobs
Published 2015-01-01

Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

by Hongtian Yang, Leah C. Graham, Alaina M. Reagan, Weronika A. Grabowska, William H. Schott, Gareth R. Howell
Published 2019-08-01

DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.

by Ileana Soto, Gareth R Howell, Cai W John, Joseph L Kief, Richard T Libby, Simon W M John
Published 2014-01-01

Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

by Hongtian Stanley Yang, Kristen D. Onos, Kwangbom Choi, Kelly J. Keezer, Daniel A. Skelly, Gregory W. Carter, Gareth R. Howell
Published 2021-02-01

A novel mouse model expressing human forms for complement receptors CR1 and CR2

by Harriet M. Jackson, Kate E. Foley, Rita O’Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell
Published 2020-09-01

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

by Pete A Williams, Gareth R Howell, Jessica M Barbay, Catherine E Braine, Gregory L Sousa, Simon W M John, James E Morgan
Published 2013-01-01

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

by Gareth R. Howell, Katharine H. MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G. Macalinao, Gregory L. Sousa, Simon W.M. John
Published 2014-11-01

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

by Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongtian S. Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John, Gareth R. Howell
Published 2020-11-01

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

by Ileana Soto, Leah C Graham, Hannah J Richter, Stephen N Simeone, Jake E Radell, Weronika Grabowska, W Keith Funkhouser, Megan C Howell, Gareth R Howell
Published 2015-10-01

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases.

by Laura G Reinholdt, Gareth R Howell, Anne M Czechanski, Danilo G Macalinao, Katharine H Macnicoll, Chyuan-Sheng Lin, Leah Rae Donahue, Simon W M John
Published 2012-01-01

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

by Harriet M Jackson, Kristen D Onos, Keating W Pepper, Leah C Graham, Ellen C Akeson, Candice Byers, Laura G Reinholdt, Wayne N Frankel, Gareth R Howell
Published 2015-01-01

Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

by Larisa Kavetsky, Kayla K. Green, Bridget R. Boyle, Fawad A. K. Yousufzai, Zachary M. Padron, Sierra E. Melli, Victoria L. Kuhnel, Harriet M. Jackson, Rosa E. Blanco, Gareth R. Howell, Ileana Soto
Published 2019-10-01

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

by Pete A. Williams, Catherine E. Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas G. Tolman, Jeffrey M. Harder, Rebecca A. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John
Published 2019-01-01

Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation.

by Kristen D Onos, Asli Uyar, Kelly J Keezer, Harriet M Jackson, Christoph Preuss, Casey J Acklin, Rita O'Rourke, Rebecca Buchanan, Travis L Cossette, Stacey J Sukoff Rizzo, Ileana Soto, Gregory W Carter, Gareth R Howell
Published 2019-05-01

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

by Christoph Preuss, Ravi Pandey, Erin Piazza, Alexander Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Lara M. Mangravite, Bruce T. Lamb, Adrian L. Oblak, Gareth R. Howell, Michael Sasner, Benjamin A. Logsdon, the MODEL-AD Consortium, Gregory W. Carter
Published 2020-11-01

A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].

by Sally H Cross, Danilo G Macalinao, Lisa McKie, Lorraine Rose, Alison L Kearney, Joe Rainger, Caroline Thaung, Margaret Keighren, Shalini Jadeja, Katrine West, Stephen C Kneeland, Richard S Smith, Gareth R Howell, Fiona Young, Morag Robertson, Rob van T' Hof, Simon W M John, Ian J Jackson
Published 2014-05-01

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

by Adrian L. Oblak, Adrian L. Oblak, Peter B. Lin, Kevin P. Kotredes, Ravi S. Pandey, Dylan Garceau, Harriet M. Williams, Asli Uyar, Rita O’Rourke, Sarah O’Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary A. Cope, Gabriela J. Little, Sean-Paul G. Williams, Carl Ash, Adam Bleckert, Tim Ragan, Benjamin A. Logsdon, Lara M. Mangravite, Stacey J. Sukoff Rizzo, Paul R. Territo, Paul R. Territo, Gregory W. Carter, Gareth R. Howell, Michael Sasner, Bruce T. Lamb, Bruce T. Lamb
Published 2021-07-01

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

by Ying-Wooi Wan, Rami Al-Ouran, Carl G. Mangleburg, Thanneer M. Perumal, Tom V. Lee, Katherine Allison, Vivek Swarup, Cory C. Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M. Neuner, Catherine C. Kaczorowski, Vivek M. Philip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E. Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B. Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J. Ebert, David C. Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A. Collier, Todd E. Golde, Allan I. Levey, David A. Bennett, Karol Estrada, T. Matthew Townsend, Bin Zhang, Eric Schadt, Philip L. De Jager, Nathan D. Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M. Shulman, Lara M. Mangravite, Benjamin A. Logsdon
Published 2020-07-01