Detecting DNA modifications from SMRT sequencing data by modeling sequence context dependence of polymerase kinetic.

by Zhixing Feng, Gang Fang, Jonas Korlach, Tyson Clark, Khai Luong, Xuegong Zhang, Wing Wong, Eric Schadt
Published 2013-01-01

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease

by Emrin Horgusluoglu-Moloch, Gaoyu Xiao, Minghui Wang, Qian Wang, Xianxiao Zhou, Kwangsik Nho, Andrew J. Saykin, Eric Schadt, Bin Zhang
Published 2020-01-01

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

by Yuji Kajiwara, Erming Wang, Minghui Wang, Wun Chey Sin, Kristen J. Brennand, Eric Schadt, Christian C. Naus, Joseph Buxbaum, Bin Zhang
Published 2018-12-01

Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution.

by Maria Lluch-Senar, Khai Luong, Verónica Lloréns-Rico, Javier Delgado, Gang Fang, Kristi Spittle, Tyson A Clark, Eric Schadt, Stephen W Turner, Jonas Korlach, Luis Serrano
Published 2013-01-01

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

by Panagiotis Douvaras, Bruce Sun, Minghui Wang, Ilya Kruglikov, Gregory Lallos, Matthew Zimmer, Cecile Terrenoire, Bin Zhang, Sam Gandy, Eric Schadt, Donald O. Freytes, Scott Noggle, Valentina Fossati
Published 2017-06-01

Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID-19

by Michael A. Kiebish, Punit Shah, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Stephane Gesta, Poornima K. Tekumalla, Chas Bountra, Elder Granger, Eric Schadt, Leonardo O. Rodrigues, Niven R. Narain
Published 2021-03-01

Hospitalised COVID-19 patients of the Mount Sinai Health System: a retrospective observational study using the electronic medical records

by Amanda Zheutlin, Yu-Han Kao, Kristin Ayers, Susan Gross, Sharon Nirenberg, Alexander Charney, Girish Nadkarni, Carol Horowitz, Glenn Martin, Andrea Branch, David Reich, William K Oh, Eric Schadt, Rong Chen
Published 2020-10-01

Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis

by Sayed Mohammad Ebrahim Sahraeian, Marghoob Mohiyuddin, Robert Sebra, Hagen Tilgner, Pegah T. Afshar, Kin Fai Au, Narges Bani Asadi, Mark B. Gerstein, Wing Hung Wong, Michael P. Snyder, Eric Schadt, Hugo Y. K. Lam
Published 2017-07-01

Protective lipid-lowering variants in healthy older individuals without coronary heart disease

by Andrew Tonkin, John J McNeil, Sophia Zoungas, Galina Polekhina, Chris Reid, Eric Schadt, Jing Pang, Paul Lacaze, Stephen Nicholls, Jane Tiller, Robert Sebra, Moeen Riaz, Amanda J Hooper, Anne M Murray, Gerald Watts
Published 2021-08-01

Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent

by Paul Lacaze, Robert Sebra, Moeen Riaz, Jodie Ingles, Jane Tiller, Bryony A. Thompson, Paul A. James, Diane Fatkin, Christopher Semsarian, Christopher M. Reid, Andrew M. Tonkin, Ingrid Winship, Eric Schadt, John J. McNeil
Published 2021-06-01

Personalized Ovarian Cancer Disease Surveillance and Detection of Candidate Therapeutic Drug Target in Circulating Tumor DNA

by John A. Martignetti, Olga Camacho-Vanegas, Nolan Priedigkeit, Catalina Camacho, Elena Pereira, Li Lin, Leopold Garnar-Wortzel, Dagny Miller, Bojan Losic, Hardik Shah, Jun Liao, Jian Ma, Pratik Lahiri, Mark Chee, Eric Schadt, Peter Dottino
Published 2014-01-01

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

by Minghui Wang, Panos Roussos, Andrew McKenzie, Xianxiao Zhou, Yuji Kajiwara, Kristen J. Brennand, Gabriele C. De Luca, John F. Crary, Patrizia Casaccia, Joseph D. Buxbaum, Michelle Ehrlich, Sam Gandy, Alison Goate, Pavel Katsel, Eric Schadt, Vahram Haroutunian, Bin Zhang
Published 2016-11-01

Personalized Circulating Tumor DNA Biomarkers Dynamically Predict Treatment Response and Survival In Gynecologic Cancers.

by Elena Pereira, Olga Camacho-Vanegas, Sanya Anand, Robert Sebra, Sandra Catalina Camacho, Leopold Garnar-Wortzel, Navya Nair, Erin Moshier, Melissa Wooten, Andrew Uzilov, Rong Chen, Monica Prasad-Hayes, Konstantin Zakashansky, Ann Marie Beddoe, Eric Schadt, Peter Dottino, John A Martignetti
Published 2015-01-01

289 PGV-001: a phase 1 trial of a personalized neoantigen peptide vaccine for the treatment of malignancies in the adjuvant setting

by Nina Bhardwaj, Marshall Posner, Philip Friedlander, John Mandeli, Sacha Gnjatic, Eric Schadt, Samir Parekh, Julia Kodysh, Alex Rubinsteyn, John Finnigan, Ana Blazquez, Mansi Saxena, Marcia Meseck, Daniela Delbeau, Matthew Galsky, Deborah Doroshow, Brett Miles, Krysztof Misiukiewicz, Hanna Irie, Amy Tiersten, Andrea Wolf, Jeffrey Hammerbacher, Michael Donovan, Rachel Brody
Published 2020-11-01

Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer

by Tú Nguyen-Dumont, James G. Dowty, Robert J. MacInnis, Jason A. Steen, Moeen Riaz, Pierre-Antoine Dugué, Anne-Laure Renault, Fleur Hammet, Maryam Mahmoodi, Derrick Theys, Helen Tsimiklis, Gianluca Severi, Damien Bolton, Paul Lacaze, Robert Sebra, Eric Schadt, John McNeil, Graham G. Giles, Roger L. Milne, Melissa C. Southey
Published 2021-03-01

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

by Daniah Trabzuni, Mina Ryten, Warren Emmett, Adaikalavan Ramasamy, Karl J Lackner, Tanja Zeller, Robert Walker, Colin Smith, Patrick A Lewis, Adamantios Mamais, Rohan de Silva, Jana Vandrovcova, International Parkinson Disease Genomics Consortium (IPDGC), Dena Hernandez, Michael A Nalls, Manu Sharma, Sophie Garnier, Suzanne Lesage, Javier Simon-Sanchez, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew Singleton, Huaibin Cai, Eric Schadt, Nicholas W Wood, Rina Bandopadhyay, Michael E Weale, John Hardy, Vincent Plagnol
Published 2013-01-01

Genomic Risk Prediction for Breast Cancer in Older Women

by Paul Lacaze, Andrew Bakshi, Moeen Riaz, Suzanne G. Orchard, Jane Tiller, Johannes T. Neumann, Prudence R. Carr, Amit D. Joshi, Yin Cao, Erica T. Warner, Alisa Manning, Tú Nguyen-Dumont, Melissa C. Southey, Roger L. Milne, Leslie Ford, Robert Sebra, Eric Schadt, Lucy Gately, Peter Gibbs, Bryony A. Thompson, Finlay A. Macrae, Paul James, Ingrid Winship, Catriona McLean, John R. Zalcberg, Robyn L. Woods, Andrew T. Chan, Anne M. Murray, John J. McNeil
Published 2021-07-01

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

by Brendan J Keating, Sam Tischfield, Sarah S Murray, Tushar Bhangale, Thomas S Price, Joseph T Glessner, Luana Galver, Jeffrey C Barrett, Struan F A Grant, Deborah N Farlow, Hareesh R Chandrupatla, Mark Hansen, Saad Ajmal, George J Papanicolaou, Yiran Guo, Mingyao Li, Stephanie Derohannessian, Paul I W de Bakker, Swneke D Bailey, Alexandre Montpetit, Andrew C Edmondson, Kent Taylor, Xiaowu Gai, Susanna S Wang, Myriam Fornage, Tamim Shaikh, Leif Groop, Michael Boehnke, Alistair S Hall, Andrew T Hattersley, Edward Frackelton, Nick Patterson, Charleston W K Chiang, Cecelia E Kim, Richard R Fabsitz, Willem Ouwehand, Alkes L Price, Patricia Munroe, Mark Caulfield, Thomas Drake, Eric Boerwinkle, David Reich, A Stephen Whitehead, Thomas P Cappola, Nilesh J Samani, A Jake Lusis, Eric Schadt, James G Wilson, Wolfgang Koenig, Mark I McCarthy, Sekar Kathiresan, Stacey B Gabriel, Hakon Hakonarson, Sonia S Anand, Muredach Reilly, James C Engert, Deborah A Nickerson, Daniel J Rader, Joel N Hirschhorn, Garret A Fitzgerald
Published 2008-01-01

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

by Ying-Wooi Wan, Rami Al-Ouran, Carl G. Mangleburg, Thanneer M. Perumal, Tom V. Lee, Katherine Allison, Vivek Swarup, Cory C. Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M. Neuner, Catherine C. Kaczorowski, Vivek M. Philip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E. Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B. Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J. Ebert, David C. Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A. Collier, Todd E. Golde, Allan I. Levey, David A. Bennett, Karol Estrada, T. Matthew Townsend, Bin Zhang, Eric Schadt, Philip L. De Jager, Nathan D. Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M. Shulman, Lara M. Mangravite, Benjamin A. Logsdon
Published 2020-07-01