Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

by Jun Wang, Anne L Brunkan, Silva Hecimovic, Emily Walker, Alison Goate
Published 2004-04-01

CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common ami...

by A Joseph Bloom, Maribel Martinez, Li-Shiun Chen, Laura J Bierut, Sharon E Murphy, Alison Goate
Published 2013-01-01

Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs.

by Satesh Ramdhani, Elisa Navarro, Evan Udine, Anastasia G Efthymiou, Brian M Schilder, Madison Parks, Alison Goate, Towfique Raj
Published 2020-02-01

Positive Selection on Loci Associated with Drug and Alcohol Dependence.

by Brooke Sadler, Gabe Haller, Howard Edenberg, Jay Tischfield, Andy Brooks, John Kramer, Marc Schuckit, John Nurnberger, Alison Goate
Published 2015-01-01

Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis.

by Bruno A Benitez, David Alvarado, Yefei Cai, Kevin Mayo, Sumitra Chakraverty, Joanne Norton, John C Morris, Mark S Sands, Alison Goate, Carlos Cruchaga
Published 2011-01-01

SORL1 variants and risk of late-onset Alzheimer’s disease

by Yonghong Li, Charles Rowland, Joseph Catanese, John Morris, Simon Lovestone, Michael C. O’Donovan, Alison Goate, Michael Owen, Julie Williams, Andrew Grupe
Published 2008-02-01

Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

by Yan Zhou, Wanjiang Zhang, Rachael Easton, James W. Ray, Patricia Lampe, Zhihong Jiang, Anne L. Brunkan, Alison Goate, Eugene M. Johnson, Jane Y. Wu
Published 2002-03-01

Dosage transmission disequilibrium test (dTDT) for linkage and association detection.

by Zhehao Zhang, Jen-Chyong Wang, William Howells, Peng Lin, Arpana Agrawal, Howard J Edenberg, Jay A Tischfield, Marc A Schuckit, Laura J Bierut, Alison Goate, John P Rice
Published 2013-01-01

A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants

by Tim W. McInerney, Brian Fulton-Howard, Christopher Patterson, Devashi Paliwal, Lars S. Jermiin, Hardip R. Patel, Judy Pa, Russell H. Swerdlow, Alison Goate, Simon Easteal, Shea J. Andrews, for the Alzheimer’s Disease Neuroimaging Initiative
Published 2021-09-01

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.

by Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham
Published 2018-11-01

Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models

by James A. Gregory, Emily Hoelzli, Rawan Abdelaal, Catherine Braine, Miguel Cuevas, Madeline Halpern, Natalie Barretto, Nadine Schrode, Güney Akbalik, Kristy Kang, Esther Cheng, Kathryn Bowles, Steven Lotz, Susan Goderie, Celeste M. Karch, Sally Temple, Alison Goate, Kristen J. Brennand, Hemali Phatnani
Published 2020-06-01

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

by Minghui Wang, Panos Roussos, Andrew McKenzie, Xianxiao Zhou, Yuji Kajiwara, Kristen J. Brennand, Gabriele C. De Luca, John F. Crary, Patrizia Casaccia, Joseph D. Buxbaum, Michelle Ehrlich, Sam Gandy, Alison Goate, Pavel Katsel, Eric Schadt, Vahram Haroutunian, Bin Zhang
Published 2016-11-01

Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

by Manav Kapoor, Michael J. Chao, Emma C. Johnson, Gloriia Novikova, Dongbing Lai, Jacquelyn L. Meyers, Jessica Schulman, John I. Nurnberger, Bernice Porjesz, Yunlong Liu, The Collaborative Study on the Genetics of Alcoholism (COGA), Tatiana Foroud, Howard J. Edenberg, Edoardo Marcora, Arpana Agrawal, Alison Goate
Published 2021-08-01

Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

by Kristin R. Wildsmith, Jacob M. Basak, Bruce W. Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E. Yarasheski, Jennifer X. Wang, Kwasi G. Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C. Sigurdson, Chengjie Xiong, Alison Goate, David M. Holtzman, Randall J. Bateman
Published 2012-01-01

In vivo human apolipoprotein E isoform fractional turnover rates in the CNS.

by Kristin R Wildsmith, Jacob M Basak, Bruce W Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E Yarasheski, Jennifer X Wang, Kwasi G Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C Sigurdson, Chengjie Xiong, Alison Goate, David M Holtzman, Randall J Bateman
Published 2012-01-01

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.

by Maria Victoria Fernández, Jong Hun Kim, John P Budde, Kathleen Black, Alexandra Medvedeva, Ben Saef, Yuetiva Deming, Jorge Del-Aguila, Laura Ibañez, Umber Dube, Oscar Harari, Joanne Norton, Rachel Chasse, John C Morris, Alison Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga
Published 2017-11-01

Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS.

by Kristin R. Wildsmith, Jacob M. Basak, Bruce W. Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E. Yarasheski, Jennifer X. Wang, Kwasi G. Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C. Sigurdson, Chengjie Xiong, Alison Goate, David M. Holtzman, Randall J. Bateman
Published 2012-01-01

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.

by Nicholas J Izzo, Jinbin Xu, Chenbo Zeng, Molly J Kirk, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Gary Look, Gilbert Rishton, Hank Safferstein, Carlos Cruchaga, Alison Goate, Michael A Cahill, Ottavio Arancio, Robert H Mach, Rolf Craven, Elizabeth Head, Harry LeVine, Tara L Spires-Jones, Susan M Catalano
Published 2014-01-01

Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood

by Jacquelyn L. Meyers, David B. Chorlian, Emma C. Johnson, Ashwini K. Pandey, Chella Kamarajan, Jessica E. Salvatore, Fazil Aliev, Stacey Subbie-Saenz de Viteri, Jian Zhang, Michael Chao, Manav Kapoor, Victor Hesselbrock, John Kramer, Samuel Kuperman, John Nurnberger, Jay Tischfield, Alison Goate, Tatiana Foroud, Danielle M. Dick, Howard J. Edenberg, Arpana Agrawal, Bernice Porjesz
Published 2019-10-01

Relationships between big‐five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease

by Andrew J. Aschenbrenner, Jennifer Petros, Eric McDade, Guoqiao Wang, David A. Balota, Tammie LS Benzinger, Carlos Cruchaga, Alison Goate, Chengjie Xiong, Richard Perrin, Anne M. Fagan, Neill Graff‐Radford, Bernardino Ghetti, Johannes Levin, Endy Weidinger, Peter Schofield, Susanne Gräber, Jae‐Hong Lee, Jasmeer P. Chhatwal, John C. Morris, Randall Bateman, Jason Hassenstab, for the Dominantly Inherited Alzheimer Network
Published 2020-01-01