Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration

by Mattia Volta, Patrick A. Lewis, Patrick A. Lewis, Evy Lobbestael
Published 2020-07-01

A Tangled Web - Tau and Sporadic Parkinson's Disease

by Selina Wray, Patrick A Lewis
Published 2010-12-01

Vesicular Dysfunction and the Pathogenesis of Parkinson’s Disease: Clues From Genetic Studies

by Kirsten Ebanks, Kirsten Ebanks, Patrick A. Lewis, Patrick A. Lewis, Rina Bandopadhyay, Rina Bandopadhyay
Published 2020-01-01

Vesicle trafficking and pathways to neurodegeneration

by Craig Blackstone, Fiona Elwood, Helene Plun-Favreau, Patrick A. Lewis
Published 2021-08-01

Computational analysis of the LRRK2 interactome

by Claudia Manzoni, Paul Denny, Ruth C. Lovering, Patrick A. Lewis
Published 2015-02-01

Cancer and neurodegeneration: between the devil and the deep blue sea.

by Hélène Plun-Favreau, Patrick A Lewis, John Hardy, L Miguel Martins, Nicholas W Wood
Published 2010-12-01

Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2

by Dimitrios Vlachakis, Nikolaos E. Labrou, Costas Iliopoulos, John Hardy, Patrick A. Lewis, Hardy Rideout, Daniah Trabzuni
Published 2018-09-01

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

by Adamantios Mamais, Meera Raja, Claudia Manzoni, Sybille Dihanich, Andrew Lees, Darren Moore, Patrick A. Lewis, Rina Bandopadhyay
Published 2013-10-01

Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

by Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark R. Cookson, Adamantios Mamais
Published 2021-03-01

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias

by Nikoleta Vavouraki, James E. Tomkins, Eleanna Kara, Henry Houlden, John Hardy, Marcus J. Tindall, Patrick A. Lewis, Claudia Manzoni
Published 2021-05-01

PINOT: an intuitive resource for integrating protein-protein interactions

by James E. Tomkins, Raffaele Ferrari, Nikoleta Vavouraki, John Hardy, Ruth C. Lovering, Patrick A. Lewis, Liam J. McGuffin, Claudia Manzoni
Published 2020-06-01

Stratification of candidate genes for Parkinson’s disease using weighted protein-protein interaction network analysis

by Raffaele Ferrari, Demis A. Kia, James E. Tomkins, John Hardy, Nicholas W. Wood, Ruth C. Lovering, Patrick A. Lewis, Claudia Manzoni
Published 2018-06-01

A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch

by Zareen Amtul, Patrick A. Lewis, Sian Piper, Richard Crook, Matt Baker, Kirk Findlay, Andrew Singleton, Marion Hogg, Linda Younkin, Steven G. Younkin, John Hardy, Michael Hutton, Bradley F. Boeve, David Tang-Wai, Todd E. Golde
Published 2002-03-01

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.

by Alastair J Noyce, Demis A Kia, Gibran Hemani, Aude Nicolas, T Ryan Price, Eduardo De Pablo-Fernandez, Philip C Haycock, Patrick A Lewis, Thomas Foltynie, George Davey Smith, International Parkinson Disease Genomics Consortium, Anette Schrag, Andrew J Lees, John Hardy, Andrew Singleton, Mike A Nalls, Neil Pearce, Debbie A Lawlor, Nicholas W Wood
Published 2017-06-01

Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue

by Michael J. Devine, Alice Kaganovich, Mina Ryten, Adamantios Mamais, Daniah Trabzuni, Claudia Manzoni, Philip McGoldrick, Diane Chan, Allissa Dillman, Julia Zerle, Susannah Horan, Jan-Willem Taanman, John Hardy, Jose-Felix Marti-Masso, Daniel Healy, Anthony H. Schapira, Benjamin Wolozin, Rina Bandopadhyay, Mark R. Cookson, Marcel P. van der Brug, Patrick A. Lewis
Published 2012-01-01

Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.

by Michael J. Devine, Alice Kaganovich, Mina Ryten, Adamantios Mamais, Daniah Trabzuni, Claudia Manzoni, Philip McGoldrick, Diane Chan, Allissa Dillman, Julia Zerle, Susannah Horan, Jan-Willem Taanman, John Hardy, Jose-Felix Marti-Masso, Daniel Healy, Anthony H. Schapira, Benjamin Wolozin, Rina Bandopadhyay, Mark R. Cookson, Marcel P. van der Brug, Patrick A. Lewis
Published 2012-01-01

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

by Laura Civiero, Susanna Cogo, Susanna Cogo, Anneleen Kiekens, Claudia Morganti, Isabella Tessari, Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Cinzia Franchin, Cinzia Franchin, Giorgio Arrigoni, Giorgio Arrigoni, Patrick A. Lewis, Giovanni Piccoli, Luigi Bubacco, Mark R. Cookson, Paolo Pinton, Elisa Greggio
Published 2017-12-01

Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.

by Michael J Devine, Alice Kaganovich, Mina Ryten, Adamantios Mamais, Daniah Trabzuni, Claudia Manzoni, Philip McGoldrick, Diane Chan, Allissa Dillman, Julia Zerle, Susannah Horan, Jan-Willem Taanman, John Hardy, Jose-Felix Marti-Masso, Daniel Healy, Anthony H Schapira, Benjamin Wolozin, Rina Bandopadhyay, Mark R Cookson, Marcel P van der Brug, Patrick A Lewis
Published 2011-01-01

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

by Daniah Trabzuni, Mina Ryten, Warren Emmett, Adaikalavan Ramasamy, Karl J Lackner, Tanja Zeller, Robert Walker, Colin Smith, Patrick A Lewis, Adamantios Mamais, Rohan de Silva, Jana Vandrovcova, International Parkinson Disease Genomics Consortium (IPDGC), Dena Hernandez, Michael A Nalls, Manu Sharma, Sophie Garnier, Suzanne Lesage, Javier Simon-Sanchez, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew Singleton, Huaibin Cai, Eric Schadt, Nicholas W Wood, Rina Bandopadhyay, Michael E Weale, John Hardy, Vincent Plagnol
Published 2013-01-01

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.

by Selina Wray, Matthew Self, NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, NINDS ALS iPSC Consortium, Patrick A Lewis, Jan-Willem Taanman, Natalie S Ryan, Colin J Mahoney, Yuying Liang, Michael J Devine, Una-Marie Sheerin, Henry Houlden, Huw R Morris, Daniel Healy, Jose-Felix Marti-Masso, Elisavet Preza, Suzanne Barker, Margaret Sutherland, Roderick A Corriveau, Michael D'Andrea, Anthony H V Schapira, Ryan J Uitti, Mark Guttman, Grzegorz Opala, Barbara Jasinska-Myga, Andreas Puschmann, Christer Nilsson, Alberto J Espay, Jaroslaw Slawek, Ludwig Gutmann, Bradley F Boeve, Kevin Boylan, A Jon Stoessl, Owen A Ross, Nicholas J Maragakis, Jay Van Gerpen, Melissa Gerstenhaber, Katrina Gwinn, Ted M Dawson, Ole Isacson, Karen S Marder, Lorraine N Clark, Serge E Przedborski, Steven Finkbeiner, Jeffrey D Rothstein, Zbigniew K Wszolek, Martin N Rossor, John Hardy
Published 2012-01-01