Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics.

The epidermal growth factor receptor (EGFR) plays a critical role in the control of cellular proliferation, differentiation, and survival. Abnormalities in EGF-EGFR signaling, such as mutations that render the EGFR hyperactive or cause overexpression of the wild-type receptor, have been found in a b...

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Bibliographic Details
Main Authors: Mark S Cragg, Junya Kuroda, Hamsa Puthalakath, David C S Huang, Andreas Strasser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC2043013?pdf=render