Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

The most prevalent single-nucleotide substitution (SNS) found in cancers is a C-to-T substitution in the CpG motif. It has been proposed that many of these SNSs arise during organismal aging, prior to transformation of a normal cell into a precancerous/cancer cell. Here, we isolated single intestina...

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Bibliographic Details
Main Authors: Natalia Lugli, Vasilis S. Dionellis, Paloma Ordóñez-Morán, Irene Kamileri, Sotirios K. Sotiriou, Joerg Huelsken, Thanos D. Halazonetis
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
precancerous lesions
APC
adenomas
organoids
mutational signatures
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307088

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http://www.sciencedirect.com/science/article/pii/S2211124717307088

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