Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

Abstract Parkinson’s disease is a multifactorial neurodegenerative disorder, the aetiology of which remains elusive. The primary clinical feature of progressively impaired motor control is caused by a loss of midbrain substantia nigra dopamine neurons that have a high α-synuclein (α-syn) and iron co...

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Bibliographic Details
Main Authors: James A. Duce, Bruce X. Wong, Hannah Durham, Jean-Christophe Devedjian, David P. Smith, David Devos
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Molecular Neurodegeneration
Subjects:
α-synuclein
Iron
Dopamine
Endosomal trafficking
Oxidative stress
Post translational modification
Online Access:http://link.springer.com/article/10.1186/s13024-017-0186-8

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http://link.springer.com/article/10.1186/s13024-017-0186-8

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