Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

Abstract The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the role of brain cholesterol homeostasis...

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Bibliographic Details
Main Authors: Vijay R. Varma, H. Büşra Lüleci, Anup M. Oommen, Sudhir Varma, Chad T. Blackshear, Michael E. Griswold, Yang An, Jackson A. Roberts, Richard O’Brien, Olga Pletnikova, Juan C. Troncoso, David A. Bennett, Tunahan Çakır, Cristina Legido-Quigley, Madhav Thambisetty
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-021-00064-9

Internet

https://doi.org/10.1038/s41514-021-00064-9

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